Förhöjt crp vid cancer
Det måste emellertid noteras att CRP är mycket ospecifikt och kan öka, speciellt under kirurgi och strålbehandling, på grund av tillhörande vävnadsskada.
Recognizing these patterns helps clinicians anticipate complications and adjust treatment accordingly.
CRP as a Prognostic Tool: What the Evidence Shows
Numerous studies have shown that elevated CRP levels are associated with poorer outcomes across various cancer types. Conversely, rising CRP levels during therapy may point to resistance, progression, or complications such as infection.
CRP can also help distinguish between true disease progression and pseudoprogression, especially in patients receiving immunotherapy.
Förutom CRP är laktatdehydrogenas (LDH) ett sådant värde.
I många cancerformer ökas ospecifika laboratorievärden direkt eller indirekt på grund av tumören. Proteiner med akut fas, inklusive CRP, produceras särskilt av levern och frigörs i blodet. It becomes a marker not only of disease severity but of systemic breakdown.
For example, a rising CRP in a patient with stable imaging may still prompt a shift in treatment goals—from aggressive intervention to comfort-focused care.
Detta kallas neutropenisk feber och är akut livshotande om den inte upptäcks snabbt och behandlas med stark antibiotika.
Utöver ökningen av CRP kan cancer också leda till andra symtom på en infektion på grund av de beskrivna mekanismerna utan att patienten faktiskt har haft en infektion. It’s not a cancer marker per se, but it provides important context about the body’s inflammatory state.
Can CRP be used to detect cancer early?
CRP alone is not specific enough to detect cancer early.
Conversely, a stable or declining CRP in a metastatic patient might support continued treatment or reduced imaging frequency.
CRP is also used alongside genomic data, patient history, and immune profiling to tailor regimens. Om många celler försvinner, som är fallet med snabbt växande tumörer, kommer mycket LDH i blodet och kan upptäckas där.
For example, in patients with early-stage cancer and high baseline CRP, closer monitoring and more aggressive follow-up may be justified. It’s more commonly used to monitor cancer progression or treatment response.
Why would CRP be high in a cancer patient without infection?
Cancer itself can provoke systemic inflammation.
If CRP levels decrease during therapy, it might suggest a positive response. Its value increases when interpreted alongside other cancer biomarkers like CA 15-3, CA 125, PSA, or circulating tumor DNA (ctDNA). They may be combined with other treatments to manage inflammation.
Does CRP play a role in skin-related cancer complications?
Absolutely.
Ett förhöjd CRP-värde märks alltid och orsaken måste alltid klargöras. For instance, patients with multiple metastases and persistently high CRP may be directed toward supportive care earlier, improving comfort and resource allocation.
Can CRP Be Used to Monitor Treatment Response?
Yes, and it’s becoming more common.
Clinicians must always take into account timing, context, and comorbid conditions when interpreting the results.
Is High CRP a Cause or a Consequence of Cancer?
This is one of the most debated questions in oncology. A falling CRP level often signals that inflammation is decreasing—either due to tumor shrinkage or effective immunomodulation.